Blar i forfatter "Shadrin, Alexey"

Viser treff 1-4 av 4

    • Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools 

      Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin S; Frei, Oleksandr; Shadrin, Alexey; Cheng, Weiqiu; Bettella, Francesco; Rødevand, Linn; Ødegaard, Ketil Joachim; Fan, Chun C; Pirinen, Matti J; Hautakangas, Heidi M; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Tronvik, Erling Andreas; Kristoffersen, Espen Saxhaug; Zwart, John Anker Henrik; Nielsen, Jonas Bille; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Stovner, Lars Jacob; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir Lingaas; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-17)
      Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are implicated in both. A shared genetic basis to migraine and mental disorders has been suggested but previous studies have reported weak or non-significant genetic correlations and five ...

    • Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts 

      Parker, Nadine; Cheng, Weiqiu; Hindley, Guy; O'Connell, Kevin Sean; Karthikeyan, Sandeep; Holen, Børge; Shadrin, Alexey; Rahman, Zillur; Karadag, Naz; Bahrami, Shahram; Lin, Aihua; Steen, Nils Eiel; Ueland, Thor; Aukrust, Pål; Djurovic, Srdjan; Dale, Anders; Smeland, Olav Bjerkehagen; Frei, Oleksandr; Andreassen, Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)
      BACKGROUND: For many brain disorders, a subset of patients jointly exhibit alterations in cortical brain structure and elevated levels of circulating immune markers. This may be driven in part by shared genetic architecture. Therefore, we investigated the phenotypic and genetic associations linking global cortical surface area and thickness with blood immune markers (i.e., white blood cell counts ...

    • Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders 

      Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-19)
      Background: Low-grade inflammation may be part of the underlying mechanism of schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain the immune activation.<p> <p<Methods: Seven immune markers were selected based on indicated associations to severe mental disorders (IL1Ra, sIL-2R, IL-18, sgp130, sTNFR-1, APRIL, ICAM-1) and measured ...

    • Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities 

      Steen, Nils Eiel; Rahman, Zillur; Szabo, Attila; Hindley, Guy; Parker, Nadine; Cheng, Weiqiu; Lin, Aihua; O'Connell, Kevin S; Sheikh, Mashhood Ahmed; Shadrin, Alexey; Bahrami, Shahram; Karthikeyan, Sandeep; Hoseth, Eva Zsuzsanna; Dale, Anders M; Aukrust, Pål; Smeland, Olav Bjerkehagen; Ueland, Thor; Frei, Oleksandr; Djurovic, Srdjan; Andreassen, Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-15)
      Background - Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-wide association studies (GWAS) have identified genetic variants associated with SCZ and immune-related phenotypes. Here, we use cutting edge statistical tools to identify shared genetic variants between SCZ and white blood cell (WBC) counts and further understand the role of the immune system in SCZ.<p> <p>Study ...